Madrid, the current La Liga champions, are closely behind Barcelona in the title race, with Atletico Madrid hot on their heels in third place.
They face a tricky trip to seventh-placed Betis on Saturday, before hosting Atletico in their Champions League last-16 first leg next Tuesday.
Mbappe has been in fine form in recent months, with 14 goals in his last 12 matches in all competitions.
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Madrid will be without the suspended Jude Bellingham but Ancelotti played down fitness concerns over midfielder Fede Valverde.
(Except for the headline, this story has not been edited by staff and is published from a syndicated feed.)